Trichloroethylene and Cancer
نویسندگان
چکیده
منابع مشابه
Trichloroethylene and cancer: epidemiologic evidence.
Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational coho...
متن کاملOccupational trichloroethylene exposure and kidney cancer risk: a meta-analysis.
OBJECTIVES Inconsistent epidemiological findings, debate over interpretation, and extrapolation of findings from animal studies to humans have produced uncertainty surrounding the carcinogenicity of trichloroethylene (TCE) exposure in occupational settings. We updated meta-analyses of published case-control and cohort studies exploring occupational TCE exposure and kidney cancer risk, incorpora...
متن کاملTrichloroethylene Cancer Epidemiology: A Consideration of Select Issues
A large body of epidemiologic evidence exists for exploring causal associations between cancer and trichloroethylene (TCE) exposure. The U.S. Environmental Protection Agency 2001 draft TCE health risk assessment concluded that epidemiologic studies, on the whole, support associations between TCE exposure and excess risk of kidney cancer, liver cancer, and lymphomas, and, to a lesser extent, cer...
متن کاملIncidence of liver cancer and trichloroethylene manufacture: joint study by industry and a cancer registry.
Marks' has described the case of a 28 year old woman who had ingested 9 g chlormezanone. She became "sleepy" and vomited, but her pulse, blood pressure, and respiration remained normal and she recovered completely within 24 hours. McChesney et a12 have reported that in man a single 400 mg oral dose of chlormezanone gave peak plasma concentrations, one to two hours after dosing, of 5-6 mg/l and ...
متن کاملTrichloroethylene (TCE)
Current evaluation Conclusion from the previous Monograph: Trichloroethylene (TCE) is probably carcinogenic to humans (Group 2A) based on limited evidence in humans for the carcinogenicity of TCE and sufficient evidence in experimental animals for the carcinogenicity of TCE. In making the overall evaluation, the Working Group considered the following evidence: (i) although the hypothesis linkin...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2013
ISSN: 1460-2105,0027-8874
DOI: 10.1093/jnci/djt131